Many interventions, protocols, and prevention methods are used to maintain or improve overall human health. The aim of some is to improve quality of life, while others specifically reduce, remove, or eradicate microbial pathogens which would otherwise cause disease.

1. What was the specific original intent of the intervention or procedure described in each of the papers and what was their unintended consequence(s)?

2. Can you offer a solution or remediation for any or all of the resulting consequences from these interventions?

3 .What is the Hygiene Hypothesis (described in the Roduit paper) and how is it related to this discussion?