SECTION A
(60 marks)

1. Steroids are endogenous hydrophobic hormones generated from cholesterol.
Identify similarities and differences between the multiple molecular targets of
endogenous steroids in humans. In your answer, focus on the:

a) Primary sequence comparisons of the molecular targets for the endogenous steroids
[3 marks]

b) Signalling characteristics of the molecular targets for the endogenous steroids
[4 marks]

c) Tissue locations of the molecular targets for the endogenous steroids
[3 marks]

Identify TWO different diseases/disorders for which named drugs in use in the clinic
target enzymes which regulate the levels of endogenous steroids.
For EACH disease,

d) Describe the pathology associated with the disease/disorder and identify the
enzyme targetted;

The substrates and products of the enzymatic reactions;
How the drug acts at molecular, cellular, organ and organismal level to treat the
disease/disorder;

Disadvantages or common adverse effects of the use of the drug; How the drug has been developed from predecessor versions to improve its usefulness.Explain