Oral vaccines versus intramuscular: a focus on HIV vaccine development

1) Assess the literature to evaluate the differences between oral, subcutaneous and intramuscular

vaccine delivery.

2) Investigate the efficacy of vaccine development for a small number of diseases to illustrate the

variability of vaccine development strategy.

3) Conduct a systematic review and meta-analysis of HIV-1 vaccines trials to identify the strategy

with the most potential.