Tour of the Cell
Basic properties of cells
What are the 3 tenets of cell theory
Who is Robert Hooke?
Who is Anton van Leeuwenhoek?
What are HeLa cells?
Who is Henrietta Lacks?
Compare and contrast prokaryotes and eukaryotes
Know and be able to label the parts of the animal cell
Describe the following eukaryotic cell components, including structure and functions:
Nucleus
Ribosome
Rough ER
Smooth ER
Golgi apparatus
Lysosomes
Vacuoles
Peroxisomes
Mitochondria
Cytoskeleton
Plasma membrane
Cell wall
Extracellular Matrix & Liver Cirrhosis
What is the extracellular matrix?
What is the general function(s) of the extracellular matrix?
What are the different molecules that make up the extracellular matrix?
How are those molecules grouped or categorized?
What is the role of Collagen in the ECM?
What is the general structure of collagen?
What is the role of Elastin in the ECM?
What is the general structure of elastin?
What is the role of Proteoglycan in the ECM?
What is the general structure of proteoglycan?
What is the role of Laminin in the ECM?
What is the general structure of laminin?
What is the role of Fibronectin in the ECM?
What is the general structure of fibronectin?
What is the role of Integrin the ECM?
What is the general structure of Integrin?
What is “outside-in” cell signaling?
What is talin?
What are the stages of wound healing?
What cells are involved in wound healing?
Why is the liver important to the proper function of the body?
Compare and contrast liver fibrosis and liver cirrhosis
What cells are important to the development of liver cirrhosis?
What are some observed abnormalities (discussed in class) in patients with liver cirrhosis?
What are TIMPs?
What are MMPs?
How do TIMPs and MMPs relate to the imbalance that occurs with liver cirrhosis?
What is CCL4?
What are animal models? Why are animal models important?
What is the CCL4 animal model?
How is the CCL4 model used to study liver cirrhosis?
What it Sirius red staining?
What characteristics does the CCL4 model have that mimic human liver cirrhosis?
Referring to what we discussed in class, what is the link between the ECM and liver cirrhosis? BE SPECIFIC
How is wound healing linked to liver cirrhosis?
Describe some therapeutic targets for liver cirrhosis treatments
Cell Junctions & Autoimmunity
What are Adhesive Junctions?
What are the different types of adhesive junctions?
Compare and contrast hemidesmisome and desmisome
What are Tight Junctions?
What is the general structure of a tight junction?
What are Gap Junctions?
What is the general structure of a gap junction?
What is the difference between Cell-Cell Junctions and Cell-Matrix Junctions
What is autoimmunity?
What is “leaky gut”?
Is leaky gut good or bad for overall health? Why?
What is microbiota dysbiosis?
Which cell junction was linked to autoimmunity in class?
What is the CIA model? How is the CIA model used to study autoimmunity?
How is disease severity measured in the CIA model?
What is Zonulin? How does Zonulin regulate tight junctions?
What is AT-1001? What is the link between AT-1001 and tight junctions?
What is AT-1002? What is the link between AT-1002 and tight junctions?
When the CIA murine model is treated with AT-1001, does disease severity improve or does disease severity get worse?
When the CIA murine model is treated with AT-1002, does disease severity improve or does disease severity get worse?
What is Rheumatoid Arthritis?
What is abnormal in Rheumatoid Arthritis?
Referring to what we discussed in class, how are tight junctions related to rheumatoid arthritis? BE SPECIFIC
